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Administration with

Qi RUI, Qin LU, Dayong WANG

《医学前沿（英文）》 2009年第3卷第1期页码 76-90 doi: 10.1007/s11684-009-0002-0

摘要： During normal metabolism, oxidative byproducts will inevitably generate and damage molecules thereby impairing their biological functions, including the aging process. (补肾抗衰方, ) is a traditional Chinese medicine widely used for clinically treating premature ovarian failure. In the present study, administration at high concentrations significantly increased lifespan, slowed aging-related decline, and delayed accumulation of aging-related cellular damage in wild-type . administration could further largely alleviate the aging defects induced by UV and oxidative stresses, and administration at different concentrations could largely rescue the aging defects in mutant animals. The protective effects of administration on aging process were at least partially dependent on the Ins/IGF-like signaling pathway. Moreover, administration at different concentrations obviously altered the expression patterns of antioxidant genes and suppressed the severe stress responses induced by UV and oxidative stresses, suggesting that -induced tolerance to UV or oxidative stress might result from reactive oxygen species scavenging. administration during development was not necessarily a requirement for UV and oxidative stress resistance, and the concentrations of administrated examined were not toxic for nematodes. Therefore, administration could effectively retrieve the aging defects induced by UV irradiation and oxidative stress in .

关键词： Bushenkangshuai Tang UV irradiation oxidative stress tissue senescence lifespan Caenorhabditis elegans

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Use of gestalt in wayfinding design and analysis of wayfinding process

NIU Li, XU Leiqing, TANG Zhong

《结构与土木工程前沿（英文）》 2008年第2卷第4期页码 386-390 doi: 10.1007/s11709-008-0040-8

摘要： The authors brought forward the definition of “Gestalt space” and indicated this kind of space can be easily cognized. Three experiments showed that “classification” and “grouping” are the human strategies to solve wayfinding problems. “Similarity” and “Legibility” of the space are advantageous to help people to complete wayfinding tasks. The designer should provide the essential “Legibility” in Gestalt space, by using some techniques such as “break” and “accession” to settle the wayfinding problem.

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Computational fluid dynamics simulation of aerosol transport and deposition

Yingjie TANG, Bing GUO

《环境科学与工程前沿（英文）》 2011年第5卷第3期页码 362-377 doi: 10.1007/s11783-011-0365-8

摘要： In this article computational fluid dynamics (CFD) simulation of aerosol transport and deposition, i.e. the transport and deposition of particles in an aerosol, is reviewed. The review gives a brief account of the basics of aerosol mechanics, followed by a description of the general CFD approach for flow field simulation, turbulence modeling, wall treatments and simulation of particle motion and deposition. Then examples from the literature are presented, including CFD simulation of particle deposition in human respiratory tract and particle deposition in aerosol devices. CFD simulation of particle transport and deposition may provide information that is difficult to obtain through physical experiments, and it may help reduce the number of experiments needed for device design. Due to the difficulty of describing turbulent flow and particle-eddy interaction, turbulent dispersion of particles remains one of the greatest challenges for CFD simulation. However, it is possible to take a balanced approach toward quantitative description of aerosol dispersion using CFD simulation in conjunction with empirical relations.

关键词： computational fluid dynamics (CFD) aerosol transport deposition

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High frequency group pulse electrochemical machining

WU Gaoyang, ZHANG Zhijing, ZHANG Weimin, TANG Xinglun

《机械工程前沿（英文）》 2007年第2卷第3期页码 293-296 doi: 10.1007/s11465-007-0051-5

摘要： In the process of machining ultrathin metal structure parts, the signal composition of high frequency group pulse, the influence of frequency to reverse current, and the design of the cathode in high frequency group pulse electrochemical machining (HGPECM) are discussed. The experiments on process were carried out. Results indicate that HGPECM can greatly improve the characteristics of the inter-electrode gap flow field, reduce electrode passivation, and obtain high machining quality. The machining quality is obviously improved by increasing the main pulse frequency. The dimensional accuracy reaches 30 40 ?m and the roughness attained is at 0.30 0.35 ?m. High frequency group pulse electrochemical machining can be successfully used in machining micro-parts.

关键词： HGPECM process machining quality passivation inter-electrode

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Data analytics and optimization for smart industry

Lixin TANG, Ying MENG

《工程管理前沿（英文）》 2021年第8卷第2期页码 157-171 doi: 10.1007/s42524-020-0126-0

摘要： Industrial intelligence is a core technology in the upgrading of the production processes and management modes of traditional industries. Motivated by the major development strategies and needs of industrial intellectualization in China, this study presents an innovative fusion structure that encompasses the theoretical foundation and technological innovation of data analytics and optimization, as well as their application to smart industrial engineering. First, this study describes a general methodology for the fusion of data analytics and optimization. Then, it identifies some data analytics and system optimization technologies to handle key issues in smart manufacturing. Finally, it provides a four-level framework for smart industry based on the theoretical and technological research on the fusion of data analytics and optimization. The framework uses data analytics to perceive and analyze industrial production and logistics processes. It also demonstrates the intelligent capability of planning, scheduling, operation optimization, and optimal control. Data analytics and system optimization technologies are employed in the four-level framework to overcome some critical issues commonly faced by manufacturing, resources and materials, energy, and logistics systems, such as high energy consumption, high costs, low energy efficiency, low resource utilization, and serious environmental pollution. The fusion of data analytics and optimization allows enterprises to enhance the prediction and control of unknown areas and discover hidden knowledge to improve decision-making efficiency. Therefore, industrial intelligence has great importance in China’s industrial upgrading and transformation into a true industrial power.

关键词： data analytics system optimization smart industry

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Safety issues of methylglyoxal and potential scavengers

Shiming LI, Siyu LIU, Chi-Tang HO

《农业科学与工程前沿（英文）》 2018年第5卷第3期页码 312-320 doi: 10.15302/J-FASE-2017174

摘要：

The health safety of methylglyoxal (MGO) has been recognized as a key issue owing to its ultra-high reactivity toward some key biomolecules such as amino acids, proteins, DNA, sulfhydryl- and basic nitrogen-containing compounds, including amino-bearing neurotransmitters. In this review, we have summarized the endo- and exogenous sources of MGO and its accumulation inside the body due to high intake, abnormal glucose metabolism and or malfunctioning glyoxalases, and review the debate concerning the adverse functionality of MGO ingested from foods. Higher than normal concentrations of MGO in the circulatory system and tissues have been found to be closely associated with the production of advanced glycation end products (AGEs), increased oxidative stress, elevated inflammation and RAGE (AGE receptors) activity, which subsequently progresses to a pathological stage of human health, such as diabetes complications, cancer, cardiovascular and degenerative diseases. Having illustrated the mechanisms of MGO trapping in vivo, we advocate the development of efficient and efficacious MGO scavengers, either assisting or enhancing the activity of endogenous glyoxalases to facilitate MGO removal, or providing phytochemicals and functional foods containing them, or pharmaceuticals to irreversibly bind MGO and thus form MGO-complexes that are cleared from the body.

关键词： reactive carbonyl species advanced glycation end products diabetes brain health methylglyoxal trapping agents

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Robust control of

Xueyan TANG, I-Ming CHEN

《机械工程前沿（英文）》 2009年第4卷第1期页码 25-34 doi: 10.1007/s11465-009-0004-2

摘要： This article describes the development of an flexure-based micromanipulator, with the features of decoupled kinematic structure, large motion range, high positioning precision, and fast response. The large motion range of flexure mechanisms is quantified by a given definition. Based on the given definition, large motion is achieved in the mechanical design of the -flexure parallel mechanism (FPM). To ensure high positioning precision and fast dynamic response, a hybrid control algorithm with both position control and vibration control are designed, using the H -theory. The controller strongly solves the three common problems of flexure mechanisms simultaneously, including unmodeled uncertainties, the external disturbances and vibration caused by inherent low damping.

关键词： robust control flexure mechanisms flexure-based micromanipulator

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A new fracture criterion for peridynamic and dual-horizon peridynamics

Jinhai ZHAO, Hesheng TANG, Songtao XUE

《结构与土木工程前沿（英文）》 2018年第12卷第4期页码 629-641 doi: 10.1007/s11709-017-0447-1

摘要： A new fracture criterion based on the crack opening displacement for peridynamic (PD) and dual-horizon peridynamics (DH-PD) is proposed. When the relative deformation of the PD bond between the particles reaches the critical crack tip opening displacement of the fracture mechanics, we assume that the bond force vanishes. A new damage rule similar to the local damage rule in conventional PD is introduced to simulate fracture. The new formulation is developed for a linear elastic solid though the extension to nonlinear materials is straightforward. The performance of the new fracture criterion is demonstrated by four examples, i.e. a bilateral crack problem, double parallel crack, monoclinic crack and the double inclined crack. The results are compared to experimental data and the results obtained by other computational methods.

关键词： Castigliano’s theorem breaking energy critical extension XFEM COD PD-COD

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Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis

Ni Wan,Mary Abernathy,Joseph Kuo-Hsiang Tang,Yinjie J. Tang,Le You

《化学科学与工程前沿（英文）》 2015年第9卷第3期页码 308-316 doi: 10.1007/s11705-015-1521-7

摘要： Cyanobacterium offers a promising chassis for phototrophic production of renewable chemicals. Although engineered cyanobacteria can achieve similar product carbon yields as heterotrophic microbial hosts, their production rate and titer under photoautotrophic conditions are 10 to 100 folds lower than those in fast growing Cyanobacterial factories face three indomitable bottlenecks. First, photosynthesis has limited ATP and NADPH generation rates. Second, CO fixation by ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) has poor efficiency. Third, CO mass transfer and light supply are deficient within large photobioreactors. On the other hand, cyanobacteria may employ organic substrates to promote phototrophic cell growth, N fixation, and metabolite synthesis. The photo-fermentations show enhanced photosynthesis, while CO loss from organic substrate degradation can be reused by the Calvin cycle. In addition, the plasticity of cyanobacterial pathways (e.g., oxidative pentose phosphate pathway and the TCA cycle) has been recently revealed to facilitate the catabolism. The use of cyanobacteria as “green ” could be a promising route to develop robust photo-biorefineries.

关键词： CO₂mass transfer N₂ fixation photosystem RuBisCO the TCA cycle

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Effect of soil crust on evaporation and dew deposition in Mu Us sandy land, China

SUN Yongliang, LI Xiaoyan, XU Heye, YANG Zhipeng, TANG Jia, ZHANG Xiaoying

《环境科学与工程前沿（英文）》 2008年第2卷第4期页码 480-486 doi: 10.1007/s11783-008-0034-8

摘要： The development of soil crust on sandy land may affect the surface hydrological process. This paper investigates the process of evaporation and dew deposition influenced by different soil surface types which were dominated by sand, primitive biotic crust, and advanced biotic crust, respectively, in the south fringe of Mu Us sandy land in Northwest China from July to September of 2006. The experimental results indicate that the advanced biotic crust could increase evaporation and dew deposition compared to the primitive biotic crust and bare sand although the differences between them were not significant. The average evaporation from advanced biotic crust, primitive biotic crust and sand was 6.8, 6.6, and 6.5 mm/d, respectively, and water content is around 16.2 % in the condition of initially identical soil. The average dew amount on advanced biotic crust was 0.116 mm/d with extreme 0.05 and 0.24 mm/d. The average values on primitive biotic crust and sand were 0.105 and 0.101 mm/d, respectively, with extreme 0.04 and 0.21 mm/d for both treatments. Also, the dew deposition on advanced biotic crust seemed stable and might rest for a longer time than that on primitive biotic crust and sand. The results suggest that the advanced biotic crust possibly facilitates evaporation and dew deposition. Therefore, the development of biotic crust may potentially enhance the hydrological circulation in the upper sand layer in sandy land.

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Permeability testing of drilling core sample from pavement

WANG Suda, TANG Zhengguang, NING Xiaojun, WU Peiguan, XING Pingyi

《结构与土木工程前沿（英文）》 2008年第2卷第4期页码 391-394 doi: 10.1007/s11709-008-0045-3

摘要： The permeability coefficient of pavement material is a very important parameter in designing the drainage of pavement structures and is also used to evaluate the quality of road construction. New equipment is used to measure the permeability coefficient of the pavement drilling core sample and relevant testing methods are introduced. Testing drilling core samples from a certain highway of Yunnan province has been proven to be feasible. The test results are also analyzed.

关键词： province material feasible permeability coefficient equipment

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Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloid leukemia

Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang, Shuhong

《医学前沿（英文）》 2019年第13卷第3期页码 378-387 doi: 10.1007/s11684-018-0658-4

摘要： Homoharringtonine (HHT), a plant alkaloid from , exhibits a unique anticancer mechanism and has been widely used in China to treat patients with acute myeloid leukemia (AML) since the 1970s. Trial SCMC-AML-2009 presented herein was a randomized clinical study designed based on our previous findings that pediatric AML patients younger than two years old may benefit from HHT-containing chemotherapy regimens. Patients randomized to arm A were treated with a standard chemotherapy regimen comprising mainly of anthracyclines and cytarabine (Ara-C), whereas patients in arm B were treated with HHT-containing regimens in which anthracyclines in all but the initial induction therapy were replaced by HHT. From February 2009 to November 2015, 59 patients less than 2 years old with AML (other than acute promyelocytic leukemia) were recruited. A total of 42 patients achieved a morphologic complete remission (CR) after the first course, with similar rates in both arms (70.6% vs.72.0%). At the end of the follow-up period, 40 patients remained in CR and 5 patients underwent hematopoietic stem cell transplantation in CR, which could not be considered as events but censors. The 5-year event-free survival (EFS) was 60.2%±9.6% for arm A and 88.0%±6.5% for arm B ( =0.024). Patients in arm B experienced shorter durations of leukopenia, neutropenia, and thrombocytopenia and had a lower risk of infection during consolidation chemotherapy with high-dosage Ara-C. Consequently, the homoharringtonine-based regimen achieved excellent EFS and alleviated hematologic toxicity for children aged younger than 2 years with AML compared with the anthracycline-based regimen.

关键词： homoharringtonine acute myeloid leukemia pediatrics

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Complete oxidation of methane on CoO-SnO catalysts

Xingfu TANG , Jiming HAO , Junhua LI ,

《环境科学与工程前沿（英文）》 2009年第3卷第3期页码 265-270 doi: 10.1007/s11783-009-0019-2

摘要： CoO-SnO hybrid oxides were prepared by the coprecipitation method and were used to oxidate methane (CH) in presence of oxygen. The CoO-SnO with a molar ratio of Co/(Co+Sn) at 0.75 exhibited the highest catalytic activity among all the CoO-SnO hybrid oxides. Experimental results showed that the catalysts were considerably stable in the CH combustion reaction, and were verified by X-ray photoelectron spectra (XPS). It was found that CoO was the active species, and SnO acted as a support or a promoting component in the CoO-SnO hybrid oxides. The surface area was not a major factor that affected catalytic activity. The hydrogen temperature-programmed reduction (H-TPR) results demonstrated that the interaction between cobalt and tin oxides accelerated the mobility of oxygen species of CoO-SnO, leading to higher catalytic activity.

关键词： Co₃O₄-SnO₂ complete oxidation methane (CH₄)

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Experimental study on average movement characteristics of bed-load particles

Limo TANG, Xingkui WANG,

《结构与土木工程前沿（英文）》 2009年第3卷第4期页码 435-439 doi: 10.1007/s11709-009-0050-1

摘要： The three-dimensional movements of bed-load particles in an open channel with different grain diameters and different specific gravities under the conditions of different hydraulic gradient are measured by means of particle tracking velocimetry (PTV) technique. The average movement characteristics of the particles are analyzed by statistics. The results show that the longitudinal average velocities of the particles neither agree with the law suggested by Einstein nor obey the law assumed by Bagnold. Einstein’s law is that the particle velocity is equal to 11.6 times of shear velocity, and the Bagnold’s law assumes the velocity equal to the difference between flow velocity at corresponding water depth and settling velocity of particle. Two formulas for determining the velocity of particle in the forms of expression given by Einstein and Bagnold are obtained according to the statistical results of experimental data, respectively.

关键词： different longitudinal three-dimensional particle Bagnold

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PD pattern recognition based on multi-fractal dimension in GIS

ZHANG Xiaoxing, YAO Yao, TANG Ju, ZHOU Qian, XU Zhongrong

《机械工程前沿（英文）》 2008年第3卷第3期页码 270-275 doi: 10.1007/s11465-008-0042-1

摘要： This paper designs four types of gas insulated substation (GIS) defect models based on partial discharge (PD) characteristics and its defections. The GIS gray intensity images are constructed based on the mass specimens gathered by the ultra-high frequency and high-speed sampling systems. The multi-fractal dimension is founded on the box-counting dimension and multi-fractal theories. The GIS gray intensity images distillation methods, based on multi-fractal characteristics, is put forward. The box-counting dimension, multi-fractal dimension, and discharge centrobaric characteristics of the PD images are also extracted. The characteristic variables are then classified by the radial basis function (RBF) network. Identified results show that the methods can effectively elevate the discrimination of the four types of defects in GIS.

关键词： substation high-speed discharge centrobaric network ultra-high frequency